Pharmaceutical industry

Amylase Enzyme and its Importance in Manufaturing process in the Pharmaceutical Industry ( let’s learn more )

“As the world of industry is witnessing tremendous changes, and the challenges facing these industries are more complex than ever before.”

“Industry has a significant impact on society, as it provides job opportunities and contributes to improving the standard of living and global development.”

The world of industries is witnessing many new materials being used in industries, which leads to their development, especially the world of medical and pharmaceutical industries.

“Industry is one of the most important sectors that contribute to the development of the national economy, and its growth opportunities are enormous.”

Now many biological materials are invading the industrial world, because biological materials have less harm and more benefits.

There is no doubt that enzymes are currently among the most important vital materials used in manufacturing, and these enzymes are among the important things in our current time, because they have become involved in many fields and industries.

As they deal with the fields of pharmaceutical industries, food industries, chemical industries, Also agriculture and environment.

So enzymes are molecules of biological catalysts. These small molecules play a vital role in all body functions, from digestion and breathing to metabolism and growth.

The study of enzymes is known as enzymology, which is a broad field that investigates the properties and functions of these complex molecules.

In this article we will talk about the amylase enzyme

1-What is amylase enzyme?

2-Types of Amylase Enzyme.
3- We will talk about the uses of the amylase enzyme in pharmaceutical manufacturing and its application in it  .

4-What are the features that make it so special and attract attention?

Let’s discover the most important enzymes in pharmaceutical manufacturing. (Let’s find out now)

1-What is amylase enzyme?

The amylase enzyme is known as a protein made in the salivary glands and is therefore a natural and vital substance that helps in the digestion of starches.

It is considered one of the enzymes that help break down complex sugars into simple sugars, which makes them easier to handle.

Moreover, there are many applications for the amylase enzyme…

Amylase enzyme has a wide range of applications in various sectors due to its ability to break down starch very efficiently.

Let’s talk about all its applications separately

Some industrial applications of amylase enzyme are as follows:

1- Pharmaceutical Industry

Amylases are used to modify the properties of starch, which is a common excipient required in tablets, capsules and other dosage forms. By breaking down starch and its impurities into simple sugars.

2- Food and Beverage Industry

-Production of sweeteners: Amylase is used to convert starch into glucose syrup, which is used as a sweetener in various food products, drinks and juices.

-Bread: Amylase helps break down the starch in bread dough.

-Clarifying fruit juice: Amylase can help clarify fruit juices by breaking down the starch that sometimes causes cloudiness.

Let’s learn more about new industry

3- Textile Industry

Desizing: Amylase is used to remove starch sizing from fabrics before dyeing and finishing processes. This improves dye uptake and fabric quality.

4- Paper Industry

Starch modification: Amylase is used to modify the properties of starch used in papermaking, which improves the strength and printability of paper.

5- Detergent Industry

Stain removal: Amylase is added to laundry detergents to help remove starch-based stains like food stains.

Starch modification: Amylases are used to modify the properties of starch, which is a common excipient required in tablets, capsules and other dosage forms. By breaking down starch and its impurities into simple sugars.

If you reached this part of the article, I would like to thank you for reading

2-Types of Amylase Enzyme.

There are three types of amylase

ɑ-amylases are found in humans, animals, plants, as well as in microbes. They are calcium metalloenzymes that cleave random α-1,4 glycosidic bonds to yield either maltose and maltotriose from amylose chains or glucose, maltose and dextrin from amylopectin chains.

𝛃- Amylase

𝛃-amylase is found in microbes and plants. It hydrolyzes the second α-1,4 glycosidic bond in the starch molecule and produces two maltose molecules at a time.

𝛄-amylases are found in plants and animals. They cleave the last α-1,4 glycosidic bond and the α-1,6 glycosidic bond in the starch molecule to yield glucose molecules. Their optimum pH is 3. They are a member of the glycosidic hydrolase family 15.

Thus, we talked about the types of amylase enzyme, which is important in drug manufacturing processes

We will talk about the uses of the amylase enzyme in pharmaceutical manufacturing and its application in it .

Amylase enzymes play a crucial role in various aspects of pharmaceutical manufacturing.

First we will speak about its important and application in drug formulation

Amylase enzymes play a valuable role in various aspects of drug formulation, offering several advantages:

1. Excipient Processing:

· Improved Handling and Mixing: Amylases can hydrolyze starches, common excipients in tablets, capsules, and other dosage forms. This reduces their viscosity, making them easier to mix and handle during the formulation process.

· Enhanced Tableting Properties: By breaking down starch molecules, amylases make them more compressible. This improves the formation of stronger, more consistent tablets with better structural integrity.

· Controlled Drug Release: Specific amylases can be used to create targeted drug delivery systems. These release the drug only after encountering specific enzymes in the body, such as amylase in the digestive tract. This allows for controlled release at the desired location and timeframe.

From the famous sayings of Dr. Sarah E. Smith: “Our understanding of how amylase works opens new horizons for developing new treatments for chronic diseases.”

2. Drug Discovery and Development:

· Solubility Enhancement: Amylases can help improve the solubility of poorly soluble drugs. By breaking down starches that might impede drug dissolution, they can increase the drug’s bioavailability and absorption in the body.

· Development of Enzymatic Assays: Amylases can be used to develop specific assays to test drug activity or stability. These assays can be highly sensitive and specific, providing valuable information during drug development.

In addition to the above, the amylase enzyme is used in advanced applications

3. Advanced Applications:

· Targeted Drug Delivery: Researchers are exploring the potential of using amylases to conjugate drugs to specific molecules. This allows for targeted delivery of the drug to specific cells or tissues in the body.

· Biocatalysis in Drug Synthesis: Amylases are being investigated for their potential use in enzymatic biocatalysis. This involves using enzymes to catalyze specific reactions during the synthesis of complex drug molecules, potentially leading to more efficient and sustainable production methods.

Sure, amylase enzyme plays a crucial role in tablet disintegration by breaking down starch-based binders and fillers, thereby facilitating faster disintegration and enhancing drug release.

· Breaks down starch-based binders and fillers: Amylase breaks down the starch molecules present in the tablet binders and fillers, which can help to loosen the tablet matrix and promote disintegration.

·  Enhances tablet dissolution: By breaking down the starch, amylase can improve the dissolution of the drug substance in the gastrointestinal tract, which is essential for its absorption into the bloodstream.

·  Faster disintegration: Amylase can accelerate the disintegration process of tablets, leading to faster drug release and potentially improving the therapeutic effect.

It is important to note that the effectiveness of amylase enzyme  in tablet disintegration depends on various factors, such as the specific type and amount of starch present, the formulation of the tablet, and the pH of the gastrointestinal environment.

It is worth mentioning that Amylase enzyme plays a crucial role in selecting excipients for tablets, particularly those containing starch. Here’s how:

1.  Compatibility: Amylase compatibility with other excipients is crucial. Incompatible excipients can hinder amylase’s ability to break down starch, affecting disintegration and drug release.

2.  Selection of starch-based excipients: Amylase is most effective with formulations containing starch-based excipients like binders and fillers. In their absence, amylase has no role to play.

3.  Tailoring amylase activity: The type and amount of amylase can be tailored based on the specific starch content and desired disintegration rate.

4.  Considering alternatives: In some cases, alternative disintegration mechanisms like super disintegrants might be preferred over amylase, especially for formulations without starch.

What are the consequences of everything we mentioned about the amylase enzyme in the pharmaceutical industry?

3. The effect of amylase enzyme on the quality of medicines
-Improves the properties of drugs

-Increases drug stability

-It improves the absorption of medications using the amylase enzyme


Now we have reached the end of our article, and we have talked about what the amylase enzyme is, and the types of this enzyme. We also informed you about the applications in which the amylase enzyme is used, and we introduced you to its great advantages.

It should be especially noted that RAWPLEX Company, which is located in China, exports materials to all importers in the Middle East.

It cannot be overlooked that the amylase enzyme from Rawplex is of high quality and efficiency, so if you are interested in raw materials, you can learn about them through the following link

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